df:
        A  B    C         D         E
0     one  A  foo  1.418757 -0.179666
1     one  B  foo -1.879024  1.291836
2     two  C  foo  0.536826 -0.009614
3   three  A  bar  1.006160  0.392149
4     one  B  bar -0.029716  0.264599
5     one  C  bar -1.146178 -0.057409
6     two  A  foo  0.100900 -1.425638
7   three  B  foo -1.035018  1.024098
8     one  C  foo  0.314665 -0.106062
9     one  A  bar -0.773723  1.824375
10    two  B  bar -1.170653  0.595974
11  three  C  bar  0.648740  1.167115

pd.pivot_table(df, values='D', index=['A', 'B'], columns=['C'])

C             bar       foo
A     B
one   A -0.773723  1.418757
      B -0.029716 -1.879024
      C -1.146178  0.314665
three A  1.006160       NaN
      B       NaN -1.035018
      C  0.648740       NaN
two   A       NaN  0.100900
      B -1.170653       NaN
      C       NaN  0.536826